| Jor. 1 | Atlético de Madrid | 5-0 | Rayo Vallecano | 04/09/21 | ||
| Jor. 2 | Real Madrid | 0-2 | Atlético de Madrid | 12/09/21 | ||
| Jor. 3 | Sporting de Huelva | 0-3 | Atlético de Madrid | 26/09/21 | ||
| Jor. 4 | Atlético de Madrid | 3-2 | Deportivo Alavés | 29/09/21 | ||
| Jor. 5 | Madrid CFF | 2-2 | Atlético de Madrid | 03/10/21 | ||
| Jor. 6 | Atlético de Madrid | 0-3 | FC Barcelona | 09/10/21 | ||
| Jor. 7 | UDG Tenerife | 1-1 | Atlético de Madrid | 17/10/21 | ||
| Jor. 8 | Atlético de Madrid | 3-0 | Villarreal CF | 31/10/21 | ||
| Jor. 9 | Valencia | 1-1 | Atlético de Madrid | 07/11/21 | ||
| Jor. 10 | Atlético de Madrid | 0-1 | Real Sociedad | 13/11/21 | ||
| Jor. 11 | SD Eibar | 0-3 | Atlético de Madrid | 21/11/21 | ||
| Jor. 12 | Atlético de Madrid | 2-1 | Levante UD | 05/12/21 | ||
| Jor. 13 | Sevilla | Atlético de Madrid | 12/12/21 (12:00h) | |||
| Jor. 14 | Atlético de Madrid | Real Betis | 18/12/21 (12:00h) | |||
| Jor. 15 | Athletic Club | Atlético de Madrid | 22/12/21 (16:00h) | |||
| Jor. 16 | Atlético de Madrid | Real Madrid | 08-09/01/22 | |||
| Jor. 17 | Villarreal | Atlético de Madrid | 11-12-13/01/22 | |||
| Jor. 18 | Atlético de Madrid | Sporting de Huelva | 15-16/01/22 | |||
| Jor. 19 | Deportivo Alavés | Atlético de Madrid | 29-30/01/22 | |||
| Jor. 20 | Atlético de Madrid | Madrid CFF | 01-02-03/02/22 | |||
| Jor. 21 | Real Sociedad | Atlético de Madrid | 05-06/02/22 | |||
| Jor. 22 | Atlético de Madrid | Sevilla | 12-13/02/22 | |||
| Jor. 23 | Atlético de Madrid | UDG Tenerife | 05-06/03/22 | |||
| Jor. 24 | Rayo Vallecano | Atlético de Madrid | 12-13/03/22 | |||
| Jor. 25 | Atlético de Madrid | Valencia | 26-27/03/22 | |||
| Jor. 26 | Real Betis | Atlético de Madrid | 02-03/04/22 | |||
| Jor. 27 | Atlético de Madrid | Athletic Club | 16-17/04/22 | |||
| Jor. 28 | Levante | Atlético de Madrid | 30/04-01/05/22 | |||
| Jor. 29 | Atlético de Madrid | SD Eibar | 07-08/05/22 | |||
| Jor. 30 | FC Barcelona | Atlético de Madrid | 14-15/05/22 |
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